The best supplements to take for overall health depend on what is missing from your diet and what stage of life you are in. For many UK adults, vitamin D in autumn and winter is the only routine addition worth considering. Folic acid before and during early pregnancy, vitamin B12 for vegans, and iron after an appropriate assessment answer more specific needs. You do not need a cupboard full of bottles.
Use the table to narrow your choices rather than as a shopping list. Food remains the usual way to meet nutrient needs; supplements make most sense when they fill an identifiable gap.

|
Supplement |
Who it’s for |
Who can probably skip it |
|---|---|---|
|
Vitamin D |
Most UK adults in autumn and winter; people with little sun exposure or darker skin throughout the year |
Someone already taking enough vitamin D in a suitable combined product |
|
Folic acid |
Anyone trying to conceive or in the first 12 weeks of pregnancy |
Adults who are not in that situation, unless advised otherwise |
|
Vitamin B12 |
Vegans, and some older adults with low intake or absorption concerns |
People getting enough B12 from food and without a relevant concern |
|
Omega-3 |
People who rarely eat oily fish and want a source of EPA and DHA |
People regularly eating oily fish |
|
Iron |
People advised to take it after a blood test and clinical assessment |
Anyone considering it solely for general wellbeing |
|
Multivitamin |
People with limited or restricted diets, or sustained periods of reduced food intake |
People whose varied diet already covers their needs |
The six supplements worth considering, and when to pass
Vitamin D: the clearest seasonal case
The NHS advises most people to consider 10 micrograms (400 IU) of vitamin D daily during autumn and winter. If you are seldom outdoors or have darker skin, it advises considering that amount all year, because you may make less vitamin D from sunlight. Vitamin D contributes to the maintenance of normal bones. Taking larger amounts without advice is unnecessary.
For the baseline, look for 10 micrograms (400 IU) on the label. D3 is a common form. Liposomal Vitamins D3 + K2 may suit someone advised to take a higher vitamin D dose; it is not the default choice for everyone. If your multivitamin already supplies the recommended amount, you may not need a separate D supplement. Taking warfarin? Speak to a pharmacist before adding vitamin K.
Folic acid: time it to pregnancy, not general wellness
The NHS recommends 400 micrograms of folic acid daily when trying to become pregnant, ideally starting three months beforehand, and for the first 12 weeks of pregnancy. Outside pregnancy planning, it is not a routine recommendation for all adults.
Choose a product that supplies 400 micrograms of folic acid, on its own or in a pregnancy-appropriate formula. Some people need a different prescribed dose, so ask a GP or midwife if your circumstances call for one. If pregnancy is not relevant and your diet is adequate, a separate folic acid tablet is unlikely to be useful. During pregnancy, avoid supplements containing vitamin A as retinol; an ordinary multivitamin may contain it.
Vitamin B12: particularly relevant if you eat vegan
Animal products provide B12, while reliable vegan food sources are limited. A vegan diet therefore needs a dependable source, whether fortified foods or a B12 supplement. Older adults with restricted intake or concerns about absorption may also need individual assessment; age alone does not dictate a bottle for everyone.
Look for vitamin B12 listed with its amount in micrograms, and follow the chosen product’s directions. The right amount depends on whether it is taken daily or less frequently and how much B12 comes from fortified food, so there is no useful one-size-fits-all dose here. If you eat enough B12-containing foods and have no reason to suspect a shortfall, a separate tablet may add little. Persistent tiredness or neurological symptoms call for medical assessment rather than self-prescribing.
Omega-3: start by looking at your fish intake
If you rarely eat oily fish, an omega-3 supplement can be a practical way to add the long-chain fats EPA and DHA. The NHS recommends at least two portions of fish a week, including one portion of oily fish. That food advice does not mean everyone needs a fish-oil capsule; people already eating oily fish regularly may have no need for one.
Compare the EPA and DHA amounts, not just the headline weight of “fish oil”: these are different figures. Fish oil and algae-derived oils offer different dietary options. There is no blanket daily dose that all adults need for general health, so use the labelled serving rather than assuming more is better. If you are pregnant, breastfeeding, on medication or choosing a cod liver oil, seek individual advice; cod liver oil can contain vitamin A, which the NHS says to avoid as a supplement during pregnancy.
Iron: only when there is a reason to take it
Iron is not a sensible “just in case” purchase. Low intake is possible, especially with a restricted diet, but tiredness alone does not establish iron deficiency. A blood test and clinical advice can show whether iron is needed and what dose to take. Too much iron can be harmful.
If advised to supplement, use the elemental iron amount and the form on the label to match the clinician’s recommendation; the total weight of an iron compound is not the same as its iron content. Ask about timing and tolerability if the product upsets your stomach. If you have not been advised to take iron after assessment, skip the separate iron supplement, including high-iron “wellness” blends.
Multivitamin: a safety net, not a substitute for meals
A multivitamin can make sense if you avoid several food groups or have eaten from a narrow range of foods for some time. A varied diet does not automatically call for extra nutrients. Use a multivitamin as a modest safety net alongside meals, while keeping targeted advice such as folic acid in early pregnancy separate.
Choose a formula with a clear daily serving and amounts you can compare with the rest of your routine. InfiniVit’s OptiVita multivitamin with fibre and live cultures offers a broader product if you would rather buy one than several separate supplements. Check its full label before adding standalone D, B6, iron or vitamin A. If you already eat well and take a supplement for a known gap, a multivitamin may duplicate it.
Why taking everything is a poor strategy
The same nutrient can appear in several bottles. Your multivitamin, energy formula and B-complex may all contain B6, while a bone formula and two other capsules may each supply vitamin D. Add up the total per day from all supplements rather than reading one front label in isolation.
The NHS advises against taking more than 10 mg of vitamin B6 a day in supplements unless a doctor advises it. Too much vitamin A, iron or vitamin D can also be harmful, and retinol-containing products need particular care in pregnancy. Buying several products costs more and makes those overlaps harder to spot.
Supplements can interact with medicines. Vitamin K matters if you take warfarin, and other ingredients may matter with other prescribed treatments. Speak to a GP or pharmacist before starting or combining products if you are pregnant, breastfeeding, taking medication or managing a health condition. In the UK, supplements are regulated as foods, not substitutes for medical treatment.
Build your own daily shortlist
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Start with food and life stage. What do you actually eat over a normal week? Note vegan or restricted eating, oily fish intake, pregnancy plans and time spent outdoors. A broad claim on a bottle tells you less than this inventory.
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Add only what addresses a real gap. UK seasonal vitamin D guidance is relevant to most adults; folic acid is tied to pregnancy planning. For possible iron deficiency or B12 absorption concerns, get individual advice rather than guessing.
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Compare every label before buying. Check the serving size, amounts and repeated ingredients across products. “100% NRV” means the nutrient reference value for labelling, not a personal prescription and not a reason to pile on another 100%.
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Review the list every few months. Diet, sun exposure and life stage change. Remove what no longer serves a purpose, and keep a note of what you take if you discuss it with a clinician.
When food intake drops for a while
During dieting or periods of reduced appetite, including for people taking appetite-reducing medication, smaller or repetitive meals may leave nutritional gaps. A broader nutritional formula may be worth considering during a sustained period of eating less. That decision is about dietary coverage, not a claim about weight loss or what a medicine does.
InfiniVit’s Replenor nutritional formula is an option in this context and is available at Holland & Barrett. Look at the complete serving and ingredients alongside anything else you take; a formula does not make meals optional. If intake stays low, discuss the cause and your nutritional needs with a healthcare professional.
The sensible verdict
The best supplements to take for health differ from person to person. For most UK adults, seasonal vitamin D is the clearest routine consideration; diet, life stage or clinical advice may give you a reason to add something else. A short list is easier to manage and less likely to duplicate nutrients. Explore the InfiniVit range for thoughtfully formulated options, or email info@infinivit.co.uk if you have a question about choosing between products.
FAQ
What is the best overall supplement to take?
There is no single best supplement for every adult. In the UK, most people should consider vitamin D at 10 micrograms (400 IU) daily in autumn and winter, while other choices depend on diet, pregnancy plans and clinical advice.
What are the best supplements for overall health?
Consider vitamin D in the UK autumn and winter, folic acid when planning pregnancy, B12 if you eat vegan, and omega-3 if you do not eat oily fish. Iron is a decision to make after a blood test and advice; a multivitamin can be a safety net if your diet is limited.
What are the top 5 supplements you should take?
There is no responsible top five that everyone should take. Start with the UK vitamin D recommendation, then add only what your diet, life stage or clinician identifies as useful; several bottles can contain the same ingredients.
What is the #1 supplement in the world?
No supplement ranks first for everyone worldwide because diets and circumstances vary. For UK adults, vitamin D has clear seasonal guidance, but folic acid takes priority when trying to conceive and iron should only be taken when advised.